CDH1/CDH2/CDH3/CDH4 (Human) Cell-Based ELISA Kit
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Specification
Product Description
CDH1/CDH2/CDH3/CDH4 (Human) Cell-Based ELISA Kit is an indirect enzyme-linked immunoassay for qualitative determination of CDH1/CDH2/CDH3/CDH4 expression in cultured cells.
Suitable Sample
Attached Cell, Loosely Attached Cell, Suspension Cell
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Qualitative
Reactivity
Human, Mouse, Rat
Regulation Status
For research use only (RUO)
Storage Instruction
Store the kit at 4°C.
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Applications
Qualitative
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Gene Info — CDH1
Entrez GeneID
999Protein Accession#
P12830 (Gene ID : 999);P19022 (Gene ID : 1000);P22223 (Gene ID : 1001);P55283 (Gene ID : 1002)Gene Name
CDH1
Gene Alias
Arc-1, CD324, CDHE, ECAD, LCAM, UVO
Gene Description
cadherin 1, type 1, E-cadherin (epithelial)
Gene Ontology
HyperlinkGene Summary
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq
Other Designations
cadherin 1, E-cadherin (epithelial)|cadherin 1, type 1|calcium-dependent adhesion protein, epithelial|cell-CAM 120/80|uvomorulin
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Gene Info — CDH2
Entrez GeneID
1000Protein Accession#
P12830 (Gene ID : 999);P19022 (Gene ID : 1000);P22223 (Gene ID : 1001);P55283 (Gene ID : 1002)Gene Name
CDH2
Gene Alias
CD325, CDHN, CDw325, NCAD
Gene Description
cadherin 2, type 1, N-cadherin (neuronal)
Omim ID
114020Gene Ontology
HyperlinkGene Summary
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq
Other Designations
N-cadherin 1|cadherin 2, N-cadherin (neuronal)|cadherin 2, type 1|calcium-dependent adhesion protein, neuronal|neural cadherin
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Gene Info — CDH3
Entrez GeneID
1001Protein Accession#
P12830 (Gene ID : 999);P19022 (Gene ID : 1000);P22223 (Gene ID : 1001);P55283 (Gene ID : 1002)Gene Name
CDH3
Gene Alias
CDHP, HJMD, PCAD
Gene Description
cadherin 3, type 1, P-cadherin (placental)
Gene Ontology
HyperlinkGene Summary
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq
Other Designations
cadherin 3, type 1|calcium-dependent adhesion protein, placental
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Gene Info — CDH4
Entrez GeneID
1002Protein Accession#
P12830 (Gene ID : 999);P19022 (Gene ID : 1000);P22223 (Gene ID : 1001);P55283 (Gene ID : 1002)Gene Name
CDH4
Gene Alias
CAD4, FLJ22202, FLJ40547, MGC126700, MGC138355, RCAD
Gene Description
cadherin 4, type 1, R-cadherin (retinal)
Omim ID
603006Gene Ontology
HyperlinkGene Summary
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. [provided by RefSeq
Other Designations
OTTHUMP00000031444|R-cadherin|cadherin 4, type 1|cadherin 4, type 1, preproprotein|retinal cadherin
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