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ADD1/ADD2 (Human) Cell-Based ELISA Kit

  • Catalog # : KA2559
  • Visit Frequency :
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  • Specification
  • Product Description:
  • ADD1/ADD2 (Human) Cell-Based ELISA Kit is an indirect enzyme-linked immunoassay for qualitative determination of ADD1/ADD2 expression in cultured cells.
  • Reactivity:
  • Human, Mouse, Rat
  • Storage Instruction:
  • Store the kit at 4°C.
  • Suitable Sample:
  • Attached Cell, Loosely Attached Cell, Suspension Cell
  • Label:
  • HRP-conjugated
  • Detection Method:
  • Colorimetric
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Qualitative
  • Application Image
  • Qualitative
  • Gene Information
  • Entrez GeneID:
  • 118
  • Protein Accession#:
  • P35611 (Gene ID : 118);P35612(Gene ID : 119)
  • Gene Name:
  • ADD1
  • Gene Alias:
  • ADDA,MGC3339,MGC44427
  • Gene Description:
  • adducin 1 (alpha)
  • Gene Summary:
  • Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000151164,OTTHUMP00000151165,erythrocyte adducin alpha subunit
  • Gene Information
  • Entrez GeneID:
  • 119
  • Protein Accession#:
  • P35611 (Gene ID : 118);P35612(Gene ID : 119)
  • Gene Name:
  • ADD2
  • Gene Alias:
  • ADDB
  • Gene Description:
  • adducin 2 (beta)
  • Gene Summary:
  • Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Various adducin beta mRNAs, alternatively spliced at 3'end and/or internally spliced and encoding different isoforms, have been described. The functions of all the different isoforms are not known. [provided by RefSeq
  • Other Designations:
  • Adducin-2 (beta),adducin 2,beta adducin
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