ACTA1/ACTC1/ACTG1/ACTG2 (Human) Cell-Based ELISA Kit
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Specification
Product Description
ACTA1/ACTC1/ACTG1/ACTG2 (Human) Cell-Based ELISA Kit is an indirect enzyme-linked immunoassay for qualitative determination of ACTA1/ACTC1/ACTG1/ACTG2 expression in cultured cells.
Suitable Sample
Attached Cell, Loosely Attached Cell, Suspension Cell
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Qualitative
Reactivity
Human, Mouse, Rat
Regulation Status
For research use only (RUO)
Storage Instruction
Store the kit at 4°C.
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Applications
Qualitative
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Gene Info — ACTA1
Entrez GeneID
58Protein Accession#
P68032 (Gene ID : 58);P63261 (Gene ID : 70);P63267 (Gene ID : 71);P68133 (Gene ID : 72)Gene Name
ACTA1
Gene Alias
ACTA, ASMA, CFTD, CFTD1, CFTDM, MPFD, NEM1, NEM2, NEM3
Gene Description
actin, alpha 1, skeletal muscle
Gene Ontology
HyperlinkGene Summary
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects. [provided by RefSeq
Other Designations
OTTHUMP00000036123|alpha skeletal muscle actin
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Gene Info — ACTC1
Entrez GeneID
70Protein Accession#
P68032 (Gene ID : 58);P63261 (Gene ID : 70);P63267 (Gene ID : 71);P68133 (Gene ID : 72)Gene Name
ACTC1
Gene Alias
ACTC, CMD1R, CMH11
Gene Description
actin, alpha, cardiac muscle 1
Gene Ontology
HyperlinkGene Summary
Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq
Other Designations
cardiac muscle alpha actin 1
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Gene Info — ACTG1
Entrez GeneID
71Protein Accession#
P68032 (Gene ID : 58);P63261 (Gene ID : 70);P63267 (Gene ID : 71);P68133 (Gene ID : 72)Gene Name
ACTG1
Gene Alias
ACT, ACTG, DFNA20, DFNA26
Gene Description
actin, gamma 1
Gene Ontology
HyperlinkGene Summary
Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in nonmuscle cells. [provided by RefSeq
Other Designations
actin, cytoplasmic 2|actin, gamma 1 propeptide|cytoskeletal gamma-actin
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Gene Info — ACTG2
Entrez GeneID
72Protein Accession#
P68032 (Gene ID : 58);P63261 (Gene ID : 70);P63267 (Gene ID : 71);P68133 (Gene ID : 72)Gene Name
ACTG2
Gene Alias
ACT, ACTA3, ACTE, ACTL3, ACTSG
Gene Description
actin, gamma 2, smooth muscle, enteric
Omim ID
102545Gene Ontology
HyperlinkGene Summary
Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 2, encoded by this gene, is a smooth muscle actin found in enteric tissues. [provided by RefSeq
Other Designations
actin, gamma 2|actin-like protein|alpha-actin 3|smooth muscle gamma actin
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Interactome
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Pathway
- Adherens junction
- Arrhythmogenic right ventricular cardiomyopathy (ARVC)
- Cardiac muscle contraction
- Focal adhesion
- Hypertrophic cardiomyopathy (HCM)
- Hypertrophic cardiomyopathy (HCM)
- Leukocyte transendothelial migration
- Pathogenic Escherichia coli infection - EHEC
- Regulation of actin cytoskeleton
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Disease
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