ELA2 (Human) ELISA Kit
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Specifications
Product Description
ELA2 (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human ELA2.
Suitable Sample
Cell Culture Samples, CSF, Milk, Plasma, Saliva, Serum, Urine
Sample Volume
50 uL
Label
Peroxidase-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
0.078 to 5 ng/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store components of the kit at 4°C or -20°C as described in the protocol.
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Applications
Quantification
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Gene Info — ELA2
Entrez GeneID
1991Gene Name
ELA2
Gene Alias
GE, HLE, HNE, NE, PMN-E
Gene Description
elastase 2, neutrophil
Gene Ontology
HyperlinkGene Summary
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq
Other Designations
bone marrow serine protease|granulocyte-derived elastase|leukocyte elastase|medullasin|polymorphonuclear elastase
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Interactomes
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Pathways
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Diseases
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