SIGLEC5 (Human) ELISA Kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human SIGLEC5.
Limit of Detection:
Quality Control Testing:
The standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed. Column A represents Assay Diluent A and column B represents Assay Diluent B.
Store the kit at -20°C. Standard should be stored at -20°C or -80°C. Avoid repeated freezing and thawing.
The sialic acid-binding immunoglobulin-like lectins (SIGLECs), such as SIGLEC5, are a subgroup of the immunoglobulin (Ig) superfamily that mediate protein-carbohydrate interactions. They specifically interact with sialic acids in glycoproteins and glycolipids, with each SIGLEC having a particular preference for both the nature of the sialic acid and its glycosidic linkage to adjacent sugars. SIGLECs have similar structures, including extracellular Ig-like domains composed of an N-terminal V-set domain followed by varying numbers of C2-set domains. It appears that all SIGLECs have an unusual arrangement of conserved cysteine residues in the V-set and adjacent C2-set domains. Most SIGLECs are expressed uniquely within the hematopoietic system (Cornish et al., 1998 [PubMed 9731071]).[supplied by OMIM