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SREBF2 Cell-Based Translocation Assay Kit

  • Catalog # : KA1378
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  • Specification
  • Product Description:
  • SREBF2 Cell-Based Translocation Assay Kit provides highly specific SREBF2 primary antibody together with a DyLight™ conjugated secondary antibody in a ready to use format.
  • Storage Instruction:
  • Store the kit at -20°C temporarily. For best results, store the components as described in the protocol.
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescence analysis of raw 264.7 cells. Panel A : Cells treated with DMSO alone demonstrate cytoplasmic localization of SREBF2, indicating that most of cells have inactive protein. Panel B : U18666A treatment for three days induced SREBF2 translocation into the nuclei, indicating that blockage of cholesterol transport in these cells activates the protein.
  • Functional Study
  • Application Image
  • Functional Study
  • Gene Information
  • Entrez GeneID:
  • 6721
  • Gene Name:
  • SREBF2
  • Gene Alias:
  • SREBP2,bHLHd2
  • Gene Description:
  • sterol regulatory element binding transcription factor 2
  • Gene Summary:
  • This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000028740,sterol regulatory element-binding protein 2,sterol regulatory element-binding transcription factor 2
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