Immunofluorescence analysis of raw 264.7 cells. Panel A : Cells treated with DMSO alone demonstrate cytoplasmic localization of SREBF2, indicating that most of cells have inactive protein. Panel B : U18666A treatment for three days induced SREBF2 translocation into the nuclei, indicating that blockage of cholesterol transport in these cells activates the protein.
This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain. [provided by RefSeq
OTTHUMP00000028740,sterol regulatory element-binding protein 2,sterol regulatory element-binding transcription factor 2