SREBF1 Transcription Factor Assay Kit
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Specification
Product Description
SREBF1 Transcription Factor Assay Kit is a method for detecting SREBF1 transcription factor DNA binding activity in nuclear extracts.
Regulation Status
For research use only (RUO)
Storage Instruction
Store the kit at -20°C temporarily. For best results, store the components as described in the protocol.
Note
Result Data
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Applications
Functional Study
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Gene Info — SREBF1
Entrez GeneID
6720Gene Name
SREBF1
Gene Alias
SREBP-1c, SREBP1, bHLHd1
Gene Description
sterol regulatory element binding transcription factor 1
Omim ID
184756Gene Ontology
HyperlinkGene Summary
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
sterol regulatory element binding protein-1
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Interactome
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Pathway
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Disease
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Publication Reference
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Apolipoprotein A4 Restricts Diet-induced Hepatic Steatosis via SREBF1-mediated Lipogenesis and Enhances IRS-PI3K-Akt Signaling.
Cheng Cheng, Xiao-Huan Liu, Jing He, Jing Gao, Jin-Ting Zhou, Jing-Na Fan, Xi Jin, Jianbo Zhang, Liao Chang, Zijun Xiong, Jun Yu, Shengbin Li, Xiaoming Li.
Molecular Nutrition & Food Research 2022 Sep; 66(18):e2101034.
Application:Func, Human, HepG2 cells.
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Apolipoprotein A4 Restricts Diet-induced Hepatic Steatosis via SREBF1-mediated Lipogenesis and Enhances IRS-PI3K-Akt Signaling.
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