SIRT3 Direct Fluorescent Screening Assay Kit
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Result Data
Result Data
Inhibition of SIRT3 by Nicotinamide (IC50= 200 uM).
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Specification
Product Description
SIRT3 Direct Fluorescent Screening Assay Kit provides a fluorescence-based method for screening SIRT3 inhibitors or activators.
Regulation Status
For research use only (RUO)
Storage Instruction
Store the kit at -80°C.
Note
Result Data
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Applications
Functional Study
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Gene Info — SIRT3
Entrez GeneID
23410Gene Name
SIRT3
Gene Alias
SIR2L3
Gene Description
sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)
Omim ID
604481Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq
Other Designations
mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase|silent mating type information regulation 2, S.cerevisiae, homolog 3|sir2-like 3|sirtuin 3|sirtuin type 3
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Interactome
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Disease
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Publication Reference
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The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3.
Ding-Kang Chen, Hui-Yan Shao, Liu Yang, Jiang-Miao Hu.
Natural Products and Bioprospecting 2022 Jan; 12(1):1.
Application：Enzyme, Human, HeLa cells.
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The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3.
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