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SIRT2 Direct Fluorescent Screening Assay Kit

  • Catalog # : KA1368
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  • Specification
  • Product Description:
  • SIRT2 Direct Fluorescent Screening Assay provides a fluorescence-based method for screening SIRT2 inhibitors or activators.
  • Storage Instruction:
  • Store the kit at -80°C temporarily. For best results, store the components as described in the protocol.
  • Note:
  • Result Data
  • Inhibition of SIRT2 by Nicotinamide (IC50= 250 uM).

  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Functional Study
  • Application Image
  • Functional Study
  • Gene Information
  • Gene Name:
  • SIRT2
  • Gene Alias:
  • Gene Description:
  • sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
  • Gene Summary:
  • This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two transcript variants result from alternative splicing of this gene. [provided by RefSeq
  • Other Designations:
  • silencing information regulator 2-like,silent information regulator 2,sir2-related protein type 2,sirtuin 2,sirtuin type 2
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