PPARD Transcription Factor Assay Kit
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Specification
Product Description
PPARD Transcription Factor Assay Kit is a non-radioactive, sensitive method for detecting PPARD transcription factor DNA binding activity in nuclear extracts.
Regulation Status
For research use only (RUO)
Storage Instruction
Store the kit at -80°C temporarily. For best results, store the components as described in the protocol.
Note
Positive Control
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Applications
Functional Study
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Gene Info — PPARD
Entrez GeneID
5467Gene Name
PPARD
Gene Alias
FAAR, MGC3931, NR1C2, NUC1, NUCI, NUCII, PPAR-beta, PPARB
Gene Description
peroxisome proliferator-activated receptor delta
Omim ID
600409Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. [provided by RefSeq
Other Designations
OTTHUMP00000016256|nuclear hormone receptor 1|peroxisome proliferative activated receptor, delta
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