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Last updated: 2017/7/16
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PPARA/PPARD/PPARG Complete Transcription Factor Assay Kit

  • Catalog # : KA1357
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  • Specification
  • Product Description:
  • PPARA/PPARD/PPARG Complete Transcription Factor Assay Kit is a non-radioactive, sensitive method for detecting PPAR-alpha, delta, gamma transcription factor DNA binding activity in nuclear extracts and whole cell lysates.
  • Storage Instruction:
  • Store the kit at -20°C temporarily. For best results, store the components as described in the protocol.
  • Note:
  • Positive Control
  • Increasing amounts of positive control (total lysate) are assayed for PPARA, PPARD, and PPARG DNA-binding activity.


  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Functional Study
  • Application Image
  • Functional Study
  • Gene Information
  • Entrez GeneID:
  • 5465
  • Gene Name:
  • PPARA
  • Gene Alias:
  • MGC2237,MGC2452,NR1C1,PPAR,hPPAR
  • Gene Description:
  • peroxisome proliferator-activated receptor alpha
  • Gene Summary:
  • Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000028713,OTTHUMP00000042872,peroxisome proliferative activated receptor, alpha,peroxisome proliferator activated receptor alpha
  • Gene Information
  • Entrez GeneID:
  • 5467
  • Gene Name:
  • PPARD
  • Gene Alias:
  • FAAR,MGC3931,NR1C2,NUC1,NUCI,NUCII,PPAR-beta,PPARB
  • Gene Description:
  • peroxisome proliferator-activated receptor delta
  • Gene Summary:
  • This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000016256,nuclear hormone receptor 1,peroxisome proliferative activated receptor, delta
  • Gene Information
  • Entrez GeneID:
  • 5468
  • Gene Name:
  • PPARG
  • Gene Alias:
  • CIMT1,NR1C3,PPARG1,PPARG2,PPARgamma
  • Gene Description:
  • peroxisome proliferator-activated receptor gamma
  • Gene Summary:
  • This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000185030,OTTHUMP00000185033,OTTHUMP00000185037,PPAR gamma,nuclear receptor subfamily 1 group C member 3,peroxisome proliferative activated receptor gamma,peroxisome proliferative activated receptor, gamma,peroxisome proliferator activated recept
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