PCSK9 (Human) ELISA Kit
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Specification
Product Description
Human PCSK9 ELISA kit is a sandwich enzyme immunoassay for the quantitative measurement of human PCSK9 in serum, plasma, cell culture medium, and other biological media.
Suitable Sample
Biological Medium, Cell Culture Medium, Plasma, Serum
Sample Volume
100 uL (1:100 prediluted)
Label
HRP-conjugate
Detection Method
Colorimetric
Assay Type
Quantitative
Intra-Assay
1.96%
Inter-Assay
4.32%
Spiking Recovery
94.23%
Calibration Range
0.16 to 10 ng/mL
Limit of Detection
0.154 ng/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Quality Control Testing
Standard curve
The standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.
Storage Instruction
Store the kit at 4°C away from light.
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Applications
Quantification
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Gene Info — PCSK9
Entrez GeneID
255738Gene Name
PCSK9
Gene Alias
FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1
Gene Description
proprotein convertase subtilisin/kexin type 9
Gene Ontology
HyperlinkGene Summary
This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3). [provided by RefSeq
Other Designations
OTTHUMP00000009833|convertase subtilisin/kexin type 9 preproprotein|neural apoptosis regulated convertase 1
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Interactome
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Disease
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Publication Reference
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PCSK9-related LDL-C value is correlated to Rab5 isoform expression level.
Naseri F, Mohammadi A, Hosseni B, Shabani M, Piran S, Soltanmohammadi E, Najafi M.
Gene Reports 2017 Mar; 6:128.
Application:Quant, Human, Blood from healthy adults.
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Serum sdLDL-C and Cellular SREBP2-Dependent Cholesterol Levels; Is There a Challenge on Targeting PCSK9?
Soltanmohammadi E, Piran S, Mohammadi A, Hosseni B, Naseri F, Shabani M, Najafi M.
Journal of Medical Biochemistry 2016 Nov; 35(4):410.
Application:Quant, Human, Serum.
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Plasma PCSK9 level affects passively LAMP-2 expression; an evidence of transcription network.
Bita Hosseni, Mohammad Shabani, Asghar Mohammadi, Faezeh Naseri, Elham Soltanmohammadi, Sadegh Piran, Mohammad Najafi.
Gene Reports 2016 Sep; 4:258.
Application:Quant, Human, Human plasma.
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PCSK9-related LDL-C value is correlated to Rab5 isoform expression level.
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