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Last updated: 2017/10/22

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F12 (Human) ELISA Kit

  • Catalog # : KA1037
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  • Specification
  • Product Description:
  • F12 (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human F12 in plasma, serum, urine, and cell culture supernatants.
  • Calibration Range:
  • 0.024 to 100 ng/mL
  • Limit of Detection:
  • 0.015 ng/mL
  • Reactivity:
  • Human
  • Storage Instruction:
  • Store components of the kit at 4°C or -20°C as described in the protocol.
  • Suitable Sample:
  • Cell Culture Supernatant, Milk, Plasma, Serum, Urine, CSF
  • Sample Volume:
  • 50 uL
  • Label:
  • Biotin-conjugate
  • Detection Method:
  • Colorimetric
  • Regulation Status:
  • For research use only (RUO)
  • Publication Reference
  • Applications
  • Quantification
  • Application Image
  • Quantification
  • Gene Information
  • Entrez GeneID:
  • 2161
  • Gene Name:
  • F12
  • Gene Alias:
  • HAE3,HAEX,HAF
  • Gene Description:
  • coagulation factor XII (Hageman factor)
  • Gene Summary:
  • This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq
  • Other Designations:
  • Hageman factor,coagulation factor XII
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