GDNF (Human) ELISA Kit
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
GDNF (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human GDNF.
Suitable Sample
Cell Culture Supernatant, Cell Lysates, Plasma (EDTA, Heparin), Serum
Sample Volume
100 uL
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
31.2 to 2000 pg/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles.
-
Applications
Quantification
-
Gene Info — GDNF
Entrez GeneID
2668Gene Name
GDNF
Gene Alias
ATF1, ATF2, HFB1-GDNF
Gene Description
glial cell derived neurotrophic factor
Gene Ontology
HyperlinkGene Summary
This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq
Other Designations
astrocyte-derived trophic factor|glial cell line derived neurotrophic factor|glial derived neurotrophic factor
-
Interactome
-
Disease
-
Publication Reference
-
Neurotrophic factor GDNF regulates intestinal barrier function in inflammatory bowel disease.
Meir M, Burkard N, Ungewiß H, Diefenbacher M, Flemming S, Kannapin F, Germer CT, Schweinlin M, Metzger M, Waschke J, Schlegel N.
The Journal of Clinical Investigation 2019 Jun; 130:120261.
Application:Quant, Human, Human serum.
-
Concentration of Glial Cell Line-Derived Neurotrophic Factor Positively Correlates with Symptoms in Functional Dyspepsia.
Tanaka F, Tominaga K, Fujikawa Y, Nagami Y, Kamata N, Yamagami H, Tanigawa T, Shiba M, Watanabe T, Fujiwara Y, Arakawa T.
Digestive Diseases and Sciences 2016 Oct; 61(12):3478.
Application:Quan, Human, Duodenal mucosa.
-
GDNF signalling through the Ret receptor tyrosine kinase.
Durbec P, Marcos-Gutierrez CV, Kilkenny C, Grigoriou M, Wartiowaara K, Suvanto P, Smith D, Ponder B, Costantini F, Saarma M, et al..
Nature 1996 Jun; 381(6585):789.
-
Human glial cell line-derived neurotrophic factor (GDNF) maps to chromosome 5.
Bermingham N, Hillermann R, Gilmour F, Martin JE, Fisher EM.
Human Genetics 1995 Dec; 96(6):671.
-
GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons.
Lin LF, Doherty DH, Lile JD, Bektesh S, Collins F.
Science 1993 May; 260(5111):1130.
-
Neurotrophic factor GDNF regulates intestinal barrier function in inflammatory bowel disease.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com