PLAU (Human) Chromogenic Activity Assay Kit (Indirect Assay)
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Specification
Product Description
PLAU (Human) Chromogenic Activity Assay Kit (Indirect Assay) is developed to determine human PLAU activity in plasma and cell culture supernatants.
Suitable Sample
Cell Culture Supernatant, Plasma, Serum
Calibration Range
0.313 to 20 IU/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store the kit at -20°C. For best results, please store the components as described in the protocol.
Avoid repeated freezing and thawing. -
Applications
Functional Study
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Gene Info — PLAU
Entrez GeneID
5328Gene Name
PLAU
Gene Alias
ATF, UPA, URK, UROKINASE, u-PA
Gene Description
plasminogen activator, urokinase
Gene Ontology
HyperlinkGene Summary
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000019849|U-plasminogen activator|antagonist of uPA|plasminogen activator, urinary|urokinase plasminogen activator|urokinase-type plasminogen activator amino-terminal fragment
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