ACTH (Human) ELISA Kit
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Specification
Product Description
ACTH (Human) ELISA Kit is used for the quantitative determination of ACTH (Adrenocorticotropic Hormone) in human plasma.
Suitable Sample
Plasma
Sample Volume
200 uL
Label
Biotin-conjugate
Detection Method
Colorimetric
Assay Type
Quantitative
Limit of Detection
1 pg/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store the kit at 4°C.
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Applications
Quantification
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Gene Info — POMC
Entrez GeneID
5443Gene Name
POMC
Gene Alias
ACTH, CLIP, LPH, MSH, NPP, POC
Gene Description
proopiomelanocortin
Gene Ontology
HyperlinkGene Summary
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq
Other Designations
OTTHUMP00000119991|adrenocorticotropic hormone|adrenocorticotropin|alpha-MSH|alpha-melanocyte-stimulating hormone|beta-LPH|beta-MSH|beta-endorphin|beta-melanocyte-stimulating hormone|corticotropin-like intermediary peptide|gamma-LPH|gamma-MSH|lipotropin b
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Interactome
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Publication Reference
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Acute hydrocortisone administration reduces cardiovagal baroreflex sensitivity and heart rate variability in young men.
Adlan AM, Veldhuijzen van Zanten JJCS, Lip GYH, Paton JFR, Kitas GD, Fisher JP.
The Journal of Physiology 2018 Oct; 596(20):4847.
Application:Quant, Human, Human plasma.
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Combined therapy of pulsed radiofrequency and nerve block in postherpetic neuralgia patients: a randomized clinical trial.
Li D, Sun G, Sun H, Wang Y, Wang Z, Yang J.
PeerJ 2018 Jun; 6:e4852.
Application:Quant, Human, Human plasma.
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Acute hydrocortisone administration reduces cardiovagal baroreflex sensitivity and heart rate variability in young men.
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