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Last updated: 2016/12/4
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Caspase-1 Assay Kit (Fluorometric)

  • Catalog # : KA0728
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  • Specification
  • Product Description:
  • Caspase-1 Assay Kit (Fluorometric) is used for detecting the activity of caspases that recognize the sequence YVAD using fluorometric method.
  • Reactivity:
  • Mammals
  • Storage Instruction:
  • Store the kit at -20°C.
  • Suitable Sample:
  • Cell Lysate
  • Detection Method:
  • Fluorometric
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Functional Study
  • Application Image
  • Functional Study
  • Gene Information
  • Entrez GeneID:
  • 834
  • Gene Name:
  • CASP1
  • Gene Alias:
  • ICE,IL1BC,P45
  • Gene Description:
  • caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
  • Gene Summary:
  • This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq
  • Other Designations:
  • CASP1 nirs variant 1,IL1B-convertase,caspase 1,caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase),interleukin 1-B converting enzyme,interleukin 1-beta convertase
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