DNMT3B Assay Kit
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Specification
Product Description
DNMT3B Assay Kit is use for measuring the amount of DNMT3B.
Regulation Status
For research use only (RUO)
Storage Instruction
Store DB3 and DB5 at -20°C away from light. Store DB4, DB6 and 8 well strips at 4°C away from light. Store other components at room temperature.
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Applications
Quantification
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Gene Info — DNMT3B
Entrez GeneID
1789Gene Name
DNMT3B
Gene Alias
ICF, M.HsaIIIB
Gene Description
DNA (cytosine-5-)-methyltransferase 3 beta
Gene Ontology
HyperlinkGene Summary
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq
Other Designations
DNA MTase HsaIIIB|DNA cytosine-5 methyltransferase 3 beta|DNA methyltransferase HsaIIIB
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