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MBD2 Binding Activity/Inhibition Assay Kit

  • Catalog # : KA0675
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  • Specification
  • Product Description:
  • MBD2 Binding Activity/Inhibition Assay Kit is use for measuring the binding activity of MBD2 to methylated DNA.
  • Storage Instruction:
  • Store MB3, MB4, MB5, MB6, and 8 well strips at 4°C away from light. Store other components at room temperature.
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Functional Study
  • Application Image
  • Functional Study
  • Gene Information
  • Entrez GeneID:
  • 8932
  • Gene Name:
  • MBD2
  • Gene Alias:
  • DKFZp586O0821,DMTase,NY-CO-41
  • Gene Description:
  • methyl-CpG binding domain protein 2
  • Gene Summary:
  • DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. [provided by RefSeq
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