SELP (Human) ELISA Kit
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Specification
Product Description
SELP (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human SELP.
Suitable Sample
cell culture supernates, serum and plasma (heparin, EDTA, citrate)
Sample Volume
100 uL
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
156 to 10000 pg/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles.
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Applications
Quantification
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Gene Info — SELP
Entrez GeneID
6403Gene Name
SELP
Gene Alias
CD62, CD62P, FLJ45155, GMP140, GRMP, LECAM3, PADGEM, PSEL
Gene Description
selectin P (granule membrane protein 140kDa, antigen CD62)
Gene Ontology
HyperlinkGene Summary
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq
Other Designations
OTTHUMP00000032609|antigen CD62|granulocyte membrane protein|leukocyte-endothelial cell adhesion molecule 3|platelet alpha-granule membrane protein|selectin P|selectin P (granule membrane protein 140kD, antigen CD62)
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Interactome
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Pathway
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Disease
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Publication Reference
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Platelet P-selectin facilitates atherosclerotic lesion development.
Burger PC, Wagner DD.
Blood 2003 Apr; 101(7):2661.
Application:Quant, Mouse, Mouse plasma.
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A new member of the sorting nexin family interacts with the C-terminus of P-selectin.
Florian V, Schluter T, Bohnensack R.
Biochemical and Biophysical Research Communications 2001 Mar; 281(4):1045.
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The P-selectin gene is highly polymorphic: reduced frequency of the Pro715 allele carriers in patients with myocardial infarction.
Herrmann SM, Ricard S, Nicaud V, Mallet C, Evans A, Ruidavets JB, Arveiler D, Luc G, Cambien F.
Human Molecular Genetics 1998 Aug; 7(8):1277.
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Platelet P-selectin facilitates atherosclerotic lesion development.
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