HP (Human) ELISA Kit
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Specification
Product Description
HP (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human HP in cell culture supernatant and urine.
Suitable Sample
Cell Culture Supernatant, Milk, Saliva, Urine
Sample Volume
50 uL
Label
Peroxidase-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Intra-Assay
5.00%
Inter-Assay
7.10%
Spiking Recovery
101.00%
Calibration Range
3.125 to 200.0 ng/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Quality Control Testing
Standard curve
The standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.
Storage Instruction
Store components of the kit at 4°C or -20°C as described in the protocol.
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Applications
Quantification
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Gene Info — HP
Entrez GeneID
3240Gene Name
HP
Gene Alias
BP, HP2-ALPHA-2, HPA1S, MGC111141
Gene Description
haptoglobin
Omim ID
140100Gene Ontology
HyperlinkGene Summary
This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
binding peptide|haptoglobin alpha(1S)-beta|haptoglobin alpha(2FS)-beta|haptoglobin, alpha polypeptide|haptoglobin, beta polypeptide
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Interactome
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Disease
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Publication Reference
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Haptoglobin polymorphisms and iron homeostasis in health and in disease.
Van Vlierberghe H, Langlois M, Delanghe J.
Clinica Chimica Acta 2004 Jul; 345(1-2):35.
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Incidence of obesity-associated cardiovascular disease is related to inflammation-sensitive plasma proteins: a population-based cohort study.
Engstrom G, Hedblad B, Stavenow L, Jonsson S, Lind P, Janzon L, Lindgarde F.
Arterioscler Thromb Vasc Biol. 2004 Aug; 24(8):1498.
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The inflammatory response in mild and in severe psoriasis.
Rocha-Pereira P, Santos-Silva A, Rebelo I, Figueiredo A, Quintanilha A, Teixeira F.
The British Journal of Dermatology 2004 May; 150(5):917.
Application:Quant, Human, Human serum.
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Haptoglobin polymorphisms and iron homeostasis in health and in disease.
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