F10 (Human) ELISA Kit
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Specification
Product Description
F10 (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human F10.
Suitable Sample
Cell Culture Samples, CSF, Milk, Plasma, Saliva, Serum and Urine
Sample Volume
50 uL
Label
Peroxidase-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
0.781 to 50 ng/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store components of the kit at 4°C or -20°C as described in the protocol.
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Applications
Quantification
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Gene Info — F10
Entrez GeneID
2159Gene Name
F10
Gene Alias
FX, FXA
Gene Description
coagulation factor X
Omim ID
227600Gene Ontology
HyperlinkGene Summary
This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. [provided by RefSeq
Other Designations
OTTHUMP00000018735|Stuart-Prower factor|factor Xa|prothrombinase
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Interactome
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Publication Reference
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Importance of substrate composition, pH and other variables on tissue factor enhancement of factor VIIa activity.
Neuenschwander PF, Branam DE, Morrissey JH.
Thromb Haemost 1993 Dec; 70(6):970.
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Cloning and expression in COS-1 cells of a full-length cDNA encoding human coagulation factor X.
Messier TL, Pittman DD, Long GL, Kaufman RJ, Church WR.
Gene 1991 Mar; 99(2):291.
Application:IP, Monkey, COS-1 cells.
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Activation of human factor X (Stuart factor) by a protease from Russell's viper venom.
Di Scipio RG, Hermodson MA, Davie EW.
Biochemistry 1977 Nov; 16(24):5253.
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Importance of substrate composition, pH and other variables on tissue factor enhancement of factor VIIa activity.
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