F7 (Human) ELISA Kit
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Specification
Product Description
F7 (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human F7.
Suitable Sample
Plasma, Serum, and cell culture samples
Sample Volume
50 uL
Label
Peroxidase-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
6.25 to 200 ng/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Quality Control Testing
Standard curve
The standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.
Storage Instruction
Store components of the kit at 4°C or -20°C as described in the protocol.
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Applications
Quantification
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Gene Info — F7
Entrez GeneID
2155Gene Name
F7
Gene Alias
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Gene Description
coagulation factor VII (serum prothrombin conversion accelerator)
Omim ID
227500Gene Ontology
HyperlinkGene Summary
This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy. [provided by RefSeq
Other Designations
FVII coagulation protein|OTTHUMP00000018733|OTTHUMP00000018734|coagulation factor VII|eptacog alfa
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Interactome
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Pathway
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Disease
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Publication Reference
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Coagulation factor VII and the risk of coronary heart disease in healthy men.
R Junker, J Heinrich, H Schulte, J van de Loo, G Assmann.
Arteriosclerosis, Thrombosis, and Vascular Biology 1997 Aug; 17(8):1539.
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Severe factor VII deficiency due to a mutation disrupting a hepatocyte nuclear factor 4 binding site in the factor VII promoter.
Arbini AA, Pollak ES, Bayleran JK, High KA, Bauer KA.
Blood 1997 Jan; 89(1):176.
Application:Quant, Human, Human plasma.
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Isolation and characterization of bovine factor VII.
Kisiel W, Davie EW.
Biochemistry 1975 Nov; 14(22):4928.
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Coagulation factor VII and the risk of coronary heart disease in healthy men.
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