APOC3 (Human) ELISA Kit
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Specification
Product Description
APOC3 (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human APOC3.
Suitable Sample
Cell culture supernates, Cell Lysates, CSF, Milk, Plasma, Serum and Urine
Sample Volume
50 uL
Label
Peroxidase-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
1.953 to 500 ng/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store components of the kit at 4°C or -20°C as described in the protocol.
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Applications
Quantification
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Gene Info — APOC3
Entrez GeneID
345Gene Name
APOC3
Gene Alias
APOCIII, MGC150353
Gene Description
apolipoprotein C-III
Omim ID
107720Gene Ontology
HyperlinkGene Summary
Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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Serum PCSK9 Correlates with PTX3 and Apolipoproteins B, A1, and C3 Concentrations in Patients with Type 2 Diabetes.
Małgorzata Waluś-Miarka, Maria Kapusta, Przemysław Miarka, Ewa Kawalec, Barbara Idzior-Waluś.
Cardiovascular Therapeutics 2021 Dec; 2021:7956161.
Application:S-ELISA, Human, Human plasma.
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The majority of lipoprotein lipase in plasma is bound to remnant lipoproteins: A new definition of remnant lipoproteins.
Sato K, Okajima F, Miyashita K, Imamura S, Kobayashi J, Stanhope KL, Havel PJ, Macida T, Sumino H, Murakami M, Schaefer E, Nakajima K.
Clinica Chimica Acta 2016 Oct; 461:114.
Application:ELISA, Human, Plasma.
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Integrating multiple 'omics' analyses identifies serological protein biomarkers for preeclampsia.
Liu LY, Yang T, Ji J, Wen Q, Morgan AA, Jin B, Chen G, Lyell DJ, Stevenson DK, Ling XB, Butte AJ.
BMC Medicine 2013 Nov; 11(1):236.
Application:ELISA, Human, Serum.
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The Effect of a Low Fructose and Low Glycemic Index/Load (FRAGILE) Dietary Intervention on Indices of Liver Function, Cardiometabolic Risk Factors, and Body Composition in Children and Adolescents With Nonalcoholic Fatty Liver Disease (NAFLD).
Mager DR, Iniguez IR, Gilmour S, Yap J.
Journal of Parenteral and Enteral Nutrition 2015 Jan; 39(1):73.
Application:ELISA, Human, Human blood.
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ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression.
Gerritsen G, Rensen PC, Kypreos KE, Zannis VI, Havekes LM, Willems van Dijk K.
Journal of Lipid Research 2005 Jul; 46(7):1466.
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Apolipoprotein C3 deficiency results in diet-induced obesity and aggravated insulin resistance in mice.
Duivenvoorden I, Teusink B, Rensen PC, Romijn JA, Havekes LM, Voshol PJ.
Diabetes 2005 Mar; 54(3):664.
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Further characterization of the metabolic properties of triglyceride-rich lipoproteins from human and mouse apoC-III transgenic mice.
Aalto-Setala K, Weinstock PH, Bisgaier CL, Wu L, Smith JD, Breslow JL.
Journal of Lipid Research 1996 Aug; 37(8):1802.
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Serum PCSK9 Correlates with PTX3 and Apolipoproteins B, A1, and C3 Concentrations in Patients with Type 2 Diabetes.
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