LBP (Human) ELISA Kit
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Specification
Product Description
LBP (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human LBP.
Suitable Sample
Plasma, Serum and other human LBP containing solutions
Sample Volume
100 uL
Label
POD-conjugate
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
1.5 to 50 ng/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store the kit at -20°C. For best results, please store the components as described in the protocol.
Avoid repeated freezing and thawing. -
Applications
Quantification
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Gene Info — LBP
Entrez GeneID
3929Gene Name
LBP
Gene Alias
MGC22233
Gene Description
lipopolysaccharide binding protein
Omim ID
151990Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene. [provided by RefSeq
Other Designations
LPS-binding protein|OTTHUMP00000030965|lipopolysaccharide-binding protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Dietary Intake of Monosaccharides from Foods is Associated with Characteristics of the Gut Microbiota and Gastrointestinal Inflammation in Healthy US Adults.
Jules A Larke, Nikita Bacalzo, Juan J Castillo, Garret Couture, Ye Chen, Zhengyao Xue, Zeynep Alkan, Mary E Kable, Carlito B Lebrilla, Charles B Stephensen, Danielle G Lemay.
The Journal of Nutrition 2023 Jan; 153(1):106.
Application:ELISA, Human, plasma.
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Impairments of intestinal arginine and NO metabolisms trigger aging-associated intestinal barrier dysfunction and 'inflammaging'.
Annette Brandt, Anja Baumann, Angélica Hernández-Arriaga, Finn Jung, Anika Nier, Raphaela Staltner, Dragana Rajcic, Christian Schmeer, Otto W Witte, Barbara Wessner, Bernhard Franzke, Karl-Heinz Wagner, Amélia Camarinha-Silva, Ina Bergheim.
Redox Biology 2022 Dec; 58:102528.
Application:Quant, Human, Plasma .
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Serum zonulin as an index of glucose dysregulation in children and adolescents with overweight and obesity.
Francesca Olivieri, Alice Maguolo, Massimiliano Corradi, Chiara Zusi, Valentina Huber, Elena Fornari, Anita Morandi, Claudio Maffeis.
International Journal of Pediatric Obesity 2022 Jun; e12946.
Application:Quant, Human, Serum.
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Association of Diet and Antimicrobial Resistance in Healthy U.S. Adults.
Andrew Oliver, Zhengyao Xue, Yirui T Villanueva, Blythe Durbin-Johnson, Zeynep Alkan, Diana H Taft, Jinxin Liu, Ian Korf, Kevin D Laugero, Charles B Stephensen, David A Mills, Mary E Kable, Danielle G Lemay.
Mbio 2022 Jun; 13(3):e0010122.
Application:Quant, Human, Human plasma.
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Immunological and behavioral responses to in vivo lipopolysaccharide administration in young and healthy obese and normal-weight humans.
Julie Lasselin, Sven Benson, Johannes Hebebrand, Karoline Boy, Vera Weskamp, Analena Handke, Till Hasenberg, Miriam Remy, Manuel Föcker, Meike Unteroberdörster, Alexandra Brinkhoff, Harald Engler, Manfred Schedlowski.
Brain, Behavior, and Immunity 2020 Aug; 88:283.
Application:Quant, Human, Human plasma.
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Novel associations of serum adropin and lipopolysaccharide-binding protein versus lipid profiles in childhood obesity.
Yuan X, Chen R, Ouyang Q, Lin X, Ai Z, Zhang Y, Yang X.
Journal of Pediatric Endocrinology & Metabolism 2020 Feb; 33(2):265.
Application:Quant, Human, Human serum.
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Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection.
Guillén Y, Noguera-Julian M, Rivera J, Casadellà M, Zevin AS, Rocafort M, Parera M, Rodríguez C, Arumí M, Carrillo J, Mothe B, Estany C, Coll J, Bravo I, Herrero C, Saz J, Sirera G, Torrella A, Navarro J, Crespo M, Negredo E, Brander C, Blanco J, Calle ML, Klatt NR, Clotet B, Paredes R.
Mucosal Immunology 2018 Aug; [Epub].
Application:ELISA, Human, Plasma.
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Stress burden and neuroendocrine regulation of cytokine production in patients with ulcerative colitis in remission.
gler H, Elsenbruch S, Rebernik L, Köcke J, Cramer H, Schöls M, Langhorst J.
Psychoneuroendocrinology 2018 Dec; 98:101.
Application:Quant, Human, Serum from patients with ulcerative colitis in remission.
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Blood concentrations of lipopolysaccharide-binding protein, high-sensitivity C-reactive protein, tumor necrosis factor-α, and Interleukin-6 in relation to insulin resistance in young adolescents.
Kim KE, Heo JS, Han S, Kwon SK, Kim SY, Kim JH, Baek KH, Sheen YH.
Clinica Chimica Acta 2018 Jul; 486:115.
Application:ELISA, Human, Plasma.
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Estrogen inhibits the overgrowth of Escherichia coli in the rat intestine under simulated microgravity.
Yang Y, Qu C, Liang S, Wang G, Han H, Chen N, Wang X, Luo Z, Zhong C, Chen Y, Li L, Wu W.
Molecular MedicineRreports 2018 Feb; 7(2):2313.
Application:Quant, Rat, Rat serum.
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Circulating lipopolysaccharide-binding protein and carotid intima-media thickness in obstructive sleep apnea.
Trojova I, Kozarova M, Petrasova D, Malachovska Z, Paranicova I, Joppa P, Tkacova R.
Physiological Research 2017 Nov; [Epub].
Application:Quant, Human, Blood from patients without obstructive sleep apnoea (OSA), patients with mild-moderate OSA and patients with severe OSA.
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Markers of intestinal permeability are already altered in early stages of non-alcoholic fatty liver disease: Studies in children.
Nier A, Engstler AJ, Maier IB, Bergheim I.
PLoS One 2017 Sep; 12(9):e0183282.
Application:Quant, Human, Plasma/Serum from non-alcoholic fatty liver disease children.
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Comparisons of the Postprandial Inflammatory and Endotoxaemic Responses to Mixed Meals in Young and Older Individuals: A Randomised Trial.
Milan AM, Pundir S, Pileggi CA, Markworth JF, Lewandowski PA, Cameron-Smith D.
Amino Acids 2017 Apr; 9(4):E354.
Application:Quant, Human , Human blood.
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Altered pattern of tumor necrosis factor-alpha production in peripheral blood monocytes from Crohn's disease.
Loganes C, Pin A, Naviglio S, Girardelli M, Bianco AM, Martelossi S, Tommasini A, Piscianz E.
World Journal of Gastroenterology 2016 Nov; 22(41):9117.
Application:Quant, Human, Plasma from patients with active Crohn’s disease, remissive Crohn’s disease, active Ulcerative Colitis, remissive Ulcerative Colitis and healthy donors (HD).
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Effects of Endurance Training on the Skeletal Muscle Nitric Oxide Metabolism in Insulin-Independent Type 2 Diabetic Men-A Pilot Study.
Brinkmann C, Schulte-Körne B, Grau M, Obels S, Kemmerling R, Schiffer T, Bloch W, Brixius K.
Metabolic Syndrome and Related Disorders 2017 Feb; 15(1):52.
Application:Quant, Human, Blood from type 2 diabetic men.
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Ischemic stroke induces gut permeability and enhances bacterial translocation leading to sepsis in aged mice.
Crapser J, Ritzel R, Verma R, Venna VR, Liu F, Chauhan A, Koellhoffer E, Patel A, Ricker A, Maas K, Graf J, McCullough LD.
Aging 2016 May; 8(5):1049.
Application:Quant, Mouse, Mouse serum.
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Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway.
Liu M, Xu Y, Han X, Yin L, Xu L, Qi Y, Zhao Y, Liu K, Peng J.
Scientific Reports 2015 Dec; 5:18038.
Application:ELISA, Mouse, Serum.
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Men and women differ in inflammatory and neuroendocrine responses to endotoxin but not in the severity of sickness symptoms.
Engler H,Benson S,Wegner A,Spreitzer I,Schedlowski M,Elsenbruch S.
Brain, Behavior, and Immunity 2016 Feb; 52:18.
Application:ELISA, Human, Plasma.
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Activated intestinal macrophages in patients with cirrhosis release NO and IL-6 that may disrupt intestinal barrier function.
Plessis JD, Vanheel H, Janssen CE, Roos L, Slavik T, Stivaktas PI, Nieuwoudt M, van Wyk SG, Vieira W, Pretorius E, Beukes M, Farre R, Tack J, Laleman W, Fevery J, Nevens F, Tania R, Van der Merwe SW.
Journal of Hepatology 2013 Jun; 58(6):1125.
Application:ELISA, Human, Human serum.
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Nonselective betablocker therapy decreases intestinal permeability and serum levels of LBP and IL-6 in patients with cirrhosis.
Reiberger T, Ferlitsch A, Payer BA, Mandorfer M, Heinisch BB, Hayden H, Lammert F, Trauner M, Peck-Radosavljevic M, Vogelsang H.
Journal of Hepatology 2012 Dec; 58(5):911.
Application:Quan, Human, Human plasma.
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Elevated levels of lipopolysaccharide-binding protein and soluble CD14 in plasma in neonatal early-onset sepsis.
Berner R, Furll B, Stelter F, Drose J, Muller HP, Schutt C.
Clinical and Diagnostic Laboratory Immunology 2002 Mar; 9(2):440.
Application:Quant, Human, Human plasma.
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A novel acute phase marker in cattle: lipopolysaccharide binding protein (LBP).
Schroedl W, Fuerll B, Reinhold P, Krueger M, Schuett C.
Journal of Endotoxin Research 2001 Jan; 7(1):49.
Application:Quant, Bovine, Bovine plasma.
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Dietary Intake of Monosaccharides from Foods is Associated with Characteristics of the Gut Microbiota and Gastrointestinal Inflammation in Healthy US Adults.
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