MMP7 (Human) ELISA Kit
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Specification
Product Description
MMP7 (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human MMP7.
Suitable Sample
Cell Culture Supernates, Serum, Plasma (Heparin), Saliva, Urine
Sample Volume
100 uL
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
156 to 10000 pg/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles.
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Applications
Quantification
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Gene Info — MMP7
Entrez GeneID
4316Gene Name
MMP7
Gene Alias
MMP-7, MPSL1, PUMP-1
Gene Description
matrix metallopeptidase 7 (matrilysin, uterine)
Omim ID
178990Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq
Other Designations
matrin|matrix metalloproteinase 7|matrix metalloproteinase 7 (matrilysin, uterine)|uterine matrilysin
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Interactome
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Pathway
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Disease
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Publication Reference
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Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans.
Zuo F, Kaminski N, Eugui E, Allard J, Yakhini Z, Ben-Dor A, Lollini L, Morris D, Kim Y, DeLustro B, Sheppard D, Pardo A, Selman M, Heller RA.
Proceedings of the National Academy of Sciences of the United States of America 2002 Apr; 99(9):6292.
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Matrilysin (MMP-7) as a significant determinant of malignant potential of early invasive colorectal carcinomas.
Masaki T, Matsuoka H, Sugiyama M, Abe N, Goto A, Sakamoto A, Atomi Y.
British Journal of Cancer 2001 May; 84(10):1317.
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Structure and expression of the human gene for the matrix metalloproteinase matrilysin.
Gaire M, Magbanua Z, McDonnell S, McNeil L, Lovett DH, Matrisian LM.
The Journal of Biological Chemistry 1994 Jan; 269(3):2032.
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Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans.
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