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T Cell Protein Tyrosine Phosphatase (TC-PTP) Fluorometric (Human) Assay Kit

  • Catalog # : KA0082
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  • Specification
  • Product Description:
  • T Cell Protein Tyrosine Phosphatase (TC-PTP) Fluorometric (Human) Assay Kit is a fluorometric and non-radioactive assay designed to measure the activity of protein tyrosine phosphatase, especially T-cell tyrosine phosphatase (TC-PTP/PTPN2).
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Dose dependent curve

    QC Testing of KA0082
    Dose dependent curve of recombinant TC-PTP.
  • Storage Instruction:
  • Store the kit at -80°C.
  • Regulation Status:
  • For research use only (RUO)
  • Publication Reference
  • Applications
  • Functional Study
  • Application Image
  • Functional Study
  • Gene Information
  • Entrez GeneID:
  • 5771
  • Gene Name:
  • PTPN2
  • Gene Alias:
  • PTPT,TC-PTP,TCELLPTP,TCPTP
  • Gene Description:
  • protein tyrosine phosphatase, non-receptor type 2
  • Gene Summary:
  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported. [provided by RefSeq
  • Other Designations:
  • T-cell protein tyrosine phosphatase
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