Wee1 Kinase (Human) Assay/Inhibitor Screening Kit is a single-site, non-quantitative immunoassay for Wee1 activity. Plates are pre-coated with a substrate corresponding to recombinant Cdc2, which contains tyrosine15 residues that can be phosphorylated by Wee1. The detector antibody specifically detects only the phosphorylated form of tyrosine15 residue on Cdc2.
This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq
WEE1+ homolog,wee1 tyrosine kinase,wee1-like protein kinase