Aurora A Kinase (Human) Assay/Inhibitor Screening Kit is a single-site, non-quantitative immunoassay for Aurora-A activity. Plates are pre-coated with a substrate corresponding to recombinant Lats2, which contains serine83 residues that can be phosphorylated by Aurora-A. The detector antibody specifically detects only the phosphorylated form of serine83 residue on Lats2.
Quality Control Testing:
Dose dependent curve
Dose dependent curve of recombinant Aurora-A enzyme reaction.
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq