Polo-like kinase 1 (Human) Assay/Inhibitor Screening Assay Kit
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More Files
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Dose dependent curve of recombinant Plk1 enzyme reaction.
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Specification
Product Description
Polo-like kinase 1 (Human) Assay/Inhibitor Screening Assay Kit is a single-site, non-quantitative immunoassay for Plk1 activity. Plates are pre-coated with a substrate corresponding to recombinant Protein-X, which contains threonine residues that can be efficiently phosphorylated by Plk1. The detector antibody specifically detects only the phosphorylated form of threonine residue on Protein-X.
Assay Type
Quantitative
Reactivity
Human
Regulation Status
For research use only (RUO)
Quality Control Testing
Dose dependent curve
Dose dependent curve of recombinant Plk1 enzyme reaction.
Storage Instruction
Store the kit at 4°C.
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Applications
Functional Study
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Gene Info — PLK1
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Interactome
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Pathway
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Disease
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Publication Reference
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Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation.
Koida N, Ozaki T, Yamamoto H, Ono S, Koda T, Ando K, Okoshi R, Kamijo T, Omura K, Nakagawara A.
The Journal of Biological Chemistry 2008 Mar; 283(13):8555.
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Molecular taxonomy of major neuronal classes in the adult mouse forebrain.
Sugino K, Hempel CM, Miller MN, Hattox AM, Shapiro P, Wu C, Huang ZJ, Nelson SB.
Nature Neuroscience 2006 Jan; 9(1):99.
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ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.
Gumireddy K, Reddy MV, Cosenza SC, Boominathan R, Baker SJ, Papathi N, Jiang J, Holland J, Reddy EP.
Cancer Cell 2005 Mar; 7(3):275.
Application：Func, Insect, HeLa cells.
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2-Amino-3-methylimidazo[4,5-f]quinoline inhibits nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells by blocking p38 kinase activation.
Y W Lee, S H Han, M Lee, K H Yang, H M Kim, Y J Jeon.
Cancer Letters 2000 Aug; 156(2):133.
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Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation.
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