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TrkA Kinase (Human) Assay/Inhibitor Screening Kit

  • Catalog # : KA0060
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  • Specification
  • Product Description:
  • TrkA Kinase (Human) Assay/Inhibitor Screening Kit is a single-site, non-quantitative immunoassay for kinase activity of recombinant catalytic domain of TrkA. Plates are pre-coated with a newly designed "Tyrosine kinase-substrate-1", which can be easily phosphorylated by recombinant catalytic domain of TrkA. The detector antibody is PY-39, an antibody that specifically detects the phosphotyrosine residue on "Tyrosine kinase-substrate-1".
  • Reactivity:
  • Human
  • Quality Control Testing:
  • Dose dependent curve

    QC Testing of KA0060
    Dose dependent curve of recombinant TrkA catalytic domain enzyme reaction.
  • Storage Instruction:
  • Store the kit at 4°C.
  • Regulation Status:
  • For research use only (RUO)
  • Publication Reference
  • Applications
  • Functional Study
  • Application Image
  • Functional Study
  • Gene Information
  • Entrez GeneID:
  • 4914
  • Gene Name:
  • NTRK1
  • Gene Alias:
  • DKFZp781I14186,MTC,TRK,TRK1,TRKA,p140-TrkA
  • Gene Description:
  • neurotrophic tyrosine kinase, receptor, type 1
  • Gene Summary:
  • This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000038736,Oncogene TRK,high affinity nerve growth factor receptor,tyrosine kinase receptor A
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