CST3 (Human) ELISA Kit
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Specification
Product Description
CST3 (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human cystatin C.
Suitable Sample
Cerebrospinal Fluid, Plasma (Citrate, EDTA, Heparin), Serum, Urine
Sample Volume
100 uL (diluted)
Label
HRP-conjugate
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
200 to 10000 ng/mL
Limit of Detection
0.25 ng/mL
Reactivity
Human, Monkey
Regulation Status
For research use only (RUO)
Quality Control Testing
Standard curve
The standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.
Storage Instruction
Store the kit at 4°C.
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Applications
Quantification
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Gene Info — CST3
Entrez GeneID
1471Gene Name
CST3
Gene Alias
ARMD11, MGC117328
Gene Description
cystatin C
Gene Ontology
HyperlinkGene Summary
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. [provided by RefSeq
Other Designations
OTTHUMP00000030440|OTTHUMP00000164181|OTTHUMP00000164182|bA218C14.4 (cystatin C)|cystatin 3|cystatin C (amyloid angiopathy and cerebral hemorrhage)|gamma-trace|neuroendocrine basic polypeptide|post-gamma-globulin
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Interactome
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Disease
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Publication Reference
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N-Acetylcysteine in Preventing Contrast-Induced Nephropathy Assessed by Cystatin C.
Alioglu E, Saygi S, Turk U, Kirilmaz B, Tuzun N, Duman C, Tengiz I, Yildiz S, Ercan E.
Cardiovascular Therapeutics 2011 Dec; 31(3):168.
Application:Quant, Human, Serum from patients with normal to subnormal GFR who were scheduled for cardiovascular procedures.
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N-Acetylcysteine in Preventing Contrast-Induced Nephropathy Assessed by Cystatin C.
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