SPANXB1 purified MaxPab mouse polyclonal antibody (B01P)
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human SPANXB1 protein.
Immunogen
SPANXB1 (NP_115850.1, 1 a.a. ~ 103 a.a) full-length human protein.
Sequence
MGQQSSVRRLKRSVPCESNEANEANEANKTMPETPTGDSDPQPAPKKMKTSESSTILVVRYRRNVKRTSPEELVNDHARENRINPDQMEEEEFIEITTERPKK
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of SPANXB1 expression in transfected 293T cell line (H00728695-T01) by SPANXB1 MaxPab polyclonal antibody.
Lane 1: SPANXB1 transfected lysate(11.33 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to SPANXB1 on Hs 181.Tes cell. [antibody concentration 10 ug/ml] -
Gene Info — SPANXB1
Entrez GeneID
728695GeneBank Accession#
NM_032461.2Protein Accession#
NP_115850.1Gene Name
SPANXB1
Gene Alias
B1, SPANX-B, SPANXB
Gene Description
SPANX family, member B1
Omim ID
300669Gene Ontology
HyperlinkGene Summary
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-tail orientation with SPANX family member B2, which appears to be a duplication of the B1 locus. The SPANXB genes are unique members of this gene family, since they contain an additional 18 nt in their coding region compared to the majority of family members. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis. [provided by RefSeq
Other Designations
OTTHUMP00000024171|nuclear-associated protein SPAN-Xb|sperm protein associated with the nucleus, X chromosome, family member B1
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Interactome
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Disease
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Publication Reference
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Cancer Testis Antigen Promotes Triple Negative Breast Cancer Metastasis and is Traceable in the Circulating Extracellular Vesicles.
Kannan A, Philley JV, Hertweck KL, Ndetan H, Singh KP, Sivakumar S, Wells RB, Vadlamudi RK, Dasgupta S.
Scientific Reports 2019 Aug; 9(1):11632.
Application:IP, IP-WB, WB-Tr, Human, SUM-159, MDA-MB-231, MCF-7, HMLE cells.
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Cancer Testis Antigen Promotes Triple Negative Breast Cancer Metastasis and is Traceable in the Circulating Extracellular Vesicles.
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