DOK7 (Human) Recombinant Protein (P01)
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More Files
- More Functions
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Specification
Product Description
Human DOK7 full-length ORF (BAC11367.1, 1 a.a. - 298 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MVGASRPPPKPLRPRQLQEVGRQSSSDSGIATGSHSSYSSSLSSYAGSSLDVWRATDELGSLLSLPAAGAPEPSLCTCLPGTVEYQVPTSLRAHYDTPRSLCLAPRDHSPPSQGSPGNSAARDSGGQTSAGCPSGWLGTRRRGLVMEAPQDSEATLPGPAPGEPWEAGGPHAGPPPAFFSACPVCGGLKGAAASAPGPATAHSGSPGPVAVDSPGPERPRGESPTYVNIPVSPSSRKQLHYMGLELQEASEGVRGAGASLYAQIDIMATETAHRVGVRHARAREEQLSELEQRKAAPQ
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
57
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — DOK7
Entrez GeneID
285489GeneBank Accession#
AK075037.1Protein Accession#
BAC11367.1Gene Name
DOK7
Gene Alias
C4orf25, Dok-7, FLJ33718, FLJ39137, FLJ90556
Gene Description
docking protein 7
Omim ID
610285Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
downstream of tyrosine kinase 7
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