IL27 (Human) Recombinant Protein (P01)
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More Files
- More Functions
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Specifications
Product Description
Human IL27 full-length ORF ( AAH62422.1, 1 a.a. - 243 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MGQTAGDLGWRLSLLLLPLLLVQAGVWGFPRPPGRPQLSLQELRREFTVSLHLARKLLAEVRGQAHRFAESHLPGVNLYLLPLGEQLPDVSLTFQAWRRLSDPERLCFISTTLQPFHALLGGLGTQGRWTNMERMQLWAMRLDLRDLQRHLRFQVLAAGFNLPEEEEEEEEEEEEERKGLLPGALGSALQGPAQVSWPQLLSTYRLLHSLELVLSRAVRELLLLSKAGHSVWPLGFPTLSPQP
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
53.9
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — IL27
Entrez GeneID
246778GeneBank Accession#
BC062422.1Protein Accession#
AAH62422.1Gene Name
IL27
Gene Alias
IL-27, IL-27A, IL27p28, IL30, MGC71873, p28
Gene Description
interleukin 27
Omim ID
608273Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq
Other Designations
IL-27 p28 subunit|OTTHUMP00000122516|interleukin 30|interleukin-27 subunit alpha
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Diseases
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Publication Reference
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Interleukin (IL)-6 Inhibits IL-27- and IL-30-Mediated Inflammatory Responses in Human Monocytes.
Petes C, Mariani MK, Yang Y, Grandvaux N, Gee K.
Frontiers in Immunology 2018 Feb; 9:256.
Application:Func, Human, THP-1 cells.
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IL-27 driven upregulation of surface HLA-E expression on monocytes inhibits IFN-γ release by autologous NK cells.
Morandi F, Airoldi I, Pistoia V.
Journal of Immunology Research 2014 Mar; 2014:938561.
Application:Added, Recombinant protein.
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Interleukin-30 expression in prostate cancer and its draining lymph nodes correlates with advanced grade and stage.
Di Meo S, Airoldi I, Sorrentino C, Zorzoli A, Esposito S, Di Carlo E.
Clinical Cancer Research 2014 Feb; 20(3):585.
Application:Incubated, Recombinant protein.
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Interleukin (IL)-6 Inhibits IL-27- and IL-30-Mediated Inflammatory Responses in Human Monocytes.
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