UBR1 monoclonal antibody (M02), clone 4G7
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant UBR1.
Immunogen
UBR1 (NP_777576, 2 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
ADEEAGGTERMEISAELPQTPQRLASWWDQQVDFYTAFLHHLAQLVPEIYFAEMDPDLEKQEESVQMSIFTPLEWYLFGEDPDICLEKLKHSGAFQLCG
Host
Mouse
Reactivity
Human
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged UBR1 is 0.3 ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to UBR1 on HeLa cell . [antibody concentration 10 ug/ml] -
Gene Info — UBR1
Entrez GeneID
197131GeneBank Accession#
NM_17491Protein Accession#
NP_777576Gene Name
UBR1
Gene Alias
JBS, MGC142065, MGC142067
Gene Description
ubiquitin protein ligase E3 component n-recognin 1
Gene Ontology
HyperlinkGene Summary
The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq
Other Designations
E3a ligase|ubiquitin ligase E3 alpha-I|ubiquitin-protein ligase E3-alpha
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Interactome
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Disease
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