AMOT purified MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of AMOT expression in transfected 293T cell line (H00154796-T01) by AMOT MaxPab polyclonal antibody.
Lane 1: AMOT transfected lysate(74.25 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human AMOT protein.
Immunogen
AMOT (NP_573572.1, 1 a.a. ~ 675 a.a) full-length human protein.
Sequence
MPRAQPSSASYQPVPADPFAIVSRAQQMVEILSDENRNLRQELEGCYEKVARLQKVETEIQRVSEAYENLVKSSSKREALEKAMRNKLEGEIRRMHDFNRDLRERLETANKQLAEKEYEGSEDTRKTISQLFAKNKESQREKEKLEAELATARSTNEDQRRHIEIRDQALSNAQAKVVKLEEELKKKQVYVDKVEKMQQALVQLQAACEKREQLEHRLRTRLERELESLRIQQRQGNCQPTNVSEYNAAALMELLREKEERILALEADMTKWEQKYLEENVMRHFALDAAATVAAQRDTTVISHSPNTSYDTALEARIQKEEEEILMANKRCLDMEGRIKTLHAQIIEKDAMIKVLQQRSRKEPSKTEQLSCMRPAKSLMSISNAGSGLLSHSSTLTGSPIMEEKRDDKSWKGSLGILLGGDYRAEYVPSTPSPVPPSTPLLSAHSKTGSRDCSTQTERGTESNKTAAVAPISVPAPVAAAATAAAITATAATITTTMVAAAPVAVAAAAAPAAAAAPSPATAAATAAAVSPAAAGQIPAAASVASAAAVAPSAAAAAAVQVAPAAPAPVPAPALVPVPAPAAAQASAPAQTQAPTSAPAVAPTPAPTPTPAVAQAEVPASPATGPGPHRLSIPSLTCNPDKTDGPVFHSNTLERKTPIQILGQEPDAEMVEYLI
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of AMOT expression in transfected 293T cell line (H00154796-T01) by AMOT MaxPab polyclonal antibody.
Lane 1: AMOT transfected lysate(74.25 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — AMOT
Entrez GeneID
154796GeneBank Accession#
NM_133265.2Protein Accession#
NP_573572.1Gene Name
AMOT
Gene Alias
KIAA1071
Gene Description
angiomotin
Omim ID
300410Gene Ontology
HyperlinkGene Summary
This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
OTTHUMP00000023866|angiomotin p130 isoform|angiomotin p80 isoform
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Interactome
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Disease
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Publication Reference
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Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover.
Nguyen HT, Andrejeva D, Gupta R, Choudhary C, Hong X, Eichhorn PJA, Loya AC, Cohen SM.
Cell Discovery 2016 Mar; 2:16001.
Application：WB-Tr, Human, HEK 293T, U-2 OS cells.
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Actin-binding and Cell Proliferation Activities of Angiomotin Family Members are Regulated by Hippo Pathway-mediated Phosphorylation.
Chan SW, Lim CJ, Guo F, Tan I, Leung T, Hong W.
The Journal of Biological Chemistry 2013 Dec; 288(52):37296.
Application：IP-WB, WB-Tr, Human, HEK 293 cells.
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Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin.
Chan SW, Lim CJ, Chong YF, Pobbati AV, Huang C, Hong W.
The Journal of Biological Chemistry 2011 Mar; 286(9):7018.
Application：WB, Human, HEK 293 cells.
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Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover.
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