TTL (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human TTL partial ORF ( NP_714923, 279 a.a. - 377 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
LESSILLQIKHIIRNCLLSVEPAISTKHLPYQSFQLFGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDIAISSVFPPPDVEQPQTQPAAFIKL
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.63
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — TTL
Entrez GeneID
150465GeneBank Accession#
NM_153712Protein Accession#
NP_714923Gene Name
TTL
Gene Alias
MGC46235
Gene Description
tubulin tyrosine ligase
Omim ID
608291Gene Ontology
HyperlinkGene Summary
TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM
Other Designations
2410003M22Rik|tubulin-tyrosine ligase
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Interactome
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Disease
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