HFE2 polyclonal antibody (A01)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant HFE2.
Immunogen
HFE2 (NP_973733, 93 a.a. ~ 173 a.a) partial recombinant protein with GST tag.
Sequence
GGCPPSQRLSRSERNRRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPS
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (35.02 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
HFE2 polyclonal antibody (A01), Lot # 060519JCS1 Western Blot analysis of HFE2 expression in U-2 OS ( Cat # L022V1 ).Western Blot (Recombinant protein)
ELISA
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Gene Info — HFE2
Entrez GeneID
148738GeneBank Accession#
NM_202004Protein Accession#
NP_973733Gene Name
HFE2
Gene Alias
HFE2A, HJV, JH, MGC23953, RGMC
Gene Description
hemochromatosis type 2 (juvenile)
Gene Ontology
HyperlinkGene Summary
The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq
Other Designations
OTTHUMP00000015582|OTTHUMP00000015583|OTTHUMP00000059680|RGM domain family, member C|hemochromatosis type 2 protein|hemojuvelin
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Disease
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Publication Reference
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Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors: NEW LINK BETWEEN HYPOXIA SIGNALING AND IRON HOMEOSTASIS.
Lakhal S, Schodel J, Townsend AR, Pugh CW, Ratcliffe PJ, Mole DR.
The Journal of Biological Chemistry 2011 Feb; 286(6):4090.
Application:WB, Human, Hep3B cells.
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Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors: NEW LINK BETWEEN HYPOXIA SIGNALING AND IRON HOMEOSTASIS.
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