PRICKLE1 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human PRICKLE1 partial ORF ( NP_694571, 684 a.a. - 756 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
DNALNLVTERKYSPKDRLRLYTPDNYEKFIQNKSAREIQAYIQNADLYGQYAHATPDYGLQNPGMNRFLGLYG
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
33.77
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PRICKLE1
Entrez GeneID
144165GeneBank Accession#
NM_153026Protein Accession#
NP_694571Gene Name
PRICKLE1
Gene Alias
EPM1B, FLJ31627, FLJ31937, MGC138902, MGC138903, RILP
Gene Description
prickle homolog 1 (Drosophila)
Omim ID
608500Gene Ontology
HyperlinkGene Summary
This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq
Other Designations
REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein|REST/NRSF-interacting LIM domain protein|prickle-like 1
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Interactome
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Pathway
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Disease
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