Western blot analysis of IL31RA over-expressed 293 cell line, cotransfected with IL31RA Validated Chimera RNAi ( Cat # H00133396-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with IL31RA monoclonal antibody (M01), clone 3A10 (Cat # H00133396-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
IL31RA is related to gp130 (IL6ST; MIM 600694), the common receptor subunit for IL6 (MIM 147620)-type cytokines. Oncostatin M receptor (OSMR; MIM 601743) and IL31RA form the heterodimeric receptor through which IL31 (MIM 609509) signals. Expression of IL31RA and OSMR mRNA is induced in activated monocytes, and both mRNAs are constitutively expressed in epithelial cells (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM
GP130 like receptor,OTTHUMP00000122547,class I cytokine receptor,gp130-like monocyte receptor,soluble type I cytokine receptor CRL3