ACMSD (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human ACMSD full-length ORF ( AAH16018.1, 1 a.a. - 278 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MGKSSEWCERIAGIQKFVLEKWTKKAKPEDTLNLCQLLNNDLASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELFPVYAAAERLKCSLFVHPWDMQMDGRMAKYWLPWLVGMPAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGFSMRPDLCAQDNPMNPKKYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELEPGKLIESMEEFDEETKNKLKAGNALAFLGLERKQFE
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
57.6
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ACMSD
Entrez GeneID
130013GeneBank Accession#
BC016018.1Protein Accession#
AAH16018.1Gene Name
ACMSD
Gene Alias
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Gene Description
aminocarboxymuconate semialdehyde decarboxylase
Omim ID
608889Gene Ontology
HyperlinkGene Summary
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM
Other Designations
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase|OTTHUMP00000162500
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Pathway
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