ACMSD monoclonal antibody (M01), clone 3A9
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of ACMSD expression in transfected 293T cell line by ACMSD monoclonal antibody (M01), clone 3A9.
Lane 1: ACMSD transfected lysate (Predicted MW: 31.2 KDa).
Lane 2: Non-transfected lysate.
Western Blot detection against Immunogen (36.74 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant ACMSD.
Immunogen
ACMSD (NP_612199, 179 a.a. ~ 278 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
SHGFSMRPDLCAQDNPMNPKKYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELEPGKLIESMEEFDEETKNKLKAGNALAFLGLERKQFE
Host
Mouse
Reactivity
Human
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of ACMSD expression in transfected 293T cell line by ACMSD monoclonal antibody (M01), clone 3A9.
Lane 1: ACMSD transfected lysate (Predicted MW: 31.2 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
ELISA
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Gene Info — ACMSD
Entrez GeneID
130013GeneBank Accession#
NM_138326Protein Accession#
NP_612199Gene Name
ACMSD
Gene Alias
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Gene Description
aminocarboxymuconate semialdehyde decarboxylase
Omim ID
608889Gene Ontology
HyperlinkGene Summary
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM
Other Designations
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase|OTTHUMP00000162500
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Pathway
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