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RASGRP4 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00115727-T01
  • Visit Frequency :
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-RASGRP4 full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 74.14
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-RASGRP4 antibody (H00115727-B01) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00115727-T01
    RASGRP4 transfected lysate.
    Western Blot
    QC Testing of H00115727-T01
    Lane 1: RASGRP4 transfected lysate ( 74.14 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Gene Name:
  • RASGRP4
  • Gene Alias:
  • -
  • Gene Description:
  • RAS guanyl releasing protein 4
  • Gene Summary:
  • The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • guanyl nucleotide releasing protein 4
  • Gene Pathway
  • Related Disease
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