TMEM123 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human TMEM123 partial ORF ( NP_443164, 34 a.a. - 133 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
ETLQHVPSDHTNETSNSTVKPPTSVASDSSNTTVTTMKPTAASNTTTPGMVSTNMTSTTLKSTPKTTSVSQNTSQISTSTMTVTHNSSVTSAASSVTITT
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.74
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — TMEM123
Entrez GeneID
114908GeneBank Accession#
NM_052932Protein Accession#
NP_443164Gene Name
TMEM123
Gene Alias
KCT3, PORIMIN, PORMIN
Gene Description
transmembrane protein 123
Omim ID
606356Gene Ontology
HyperlinkGene Summary
This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq
Other Designations
keratinocytes associated transmembrane protein 3|pro oncosis receptor inducing membrane injury|pro-oncosis receptor inducing membrane injury|serine/threonine-rich receptor
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