FBXO32 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-FBXO32 full-length
Host
Human
Theoretical MW (kDa)
39.16
Interspecies Antigen Sequence
Mouse (96); Rat (95)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-FBXO32 antibody (H00114907-B01) by Western Blots.
SDS-PAGE Gel
FBXO32 transfected lysate.
Western Blot
Lane 1: FBXO32 transfected lysate ( 39.16 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — FBXO32
Entrez GeneID
114907GeneBank Accession#
NM_058229.2Protein Accession#
ENSP00000287396Gene Name
FBXO32
Gene Alias
FLJ32424, Fbx32, MAFbx, MGC33610
Gene Description
F-box protein 32
Omim ID
606604Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing of this gene results in two transcript variants encoding two isoforms of different sizes. [provided by RefSeq
Other Designations
F-box only protein 32|atrogin 1|muscle atrophy F-box protein
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