TIRAP MaxPab rabbit polyclonal antibody (D01)
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human TIRAP protein.
Immunogen
TIRAP (AAH32474.1, 1 a.a. ~ 256 a.a) full-length human protein.
Sequence
MASSTSLPAPGSRPKKPLGKMADWFRQTLLKKPKKRPNSPESTSSDASQPTSQDSPLPPSLSSVTSPSLPPTHASDSGSSRWSKDYDVCVCHSEEDLVAAQDLVSYLEGSTASLRCFLQLRDATPGGAIVSELCQALSSSHCRVLLITPGFLQDPWCKYQMLQALTEAPGAEGCTIPLLSGLSRAAYPPELRFMYYVDGRGPDGGFRQVKEAVMRYLQTLSWHLLYHGTPEIGVKLETENPCRASDSHKCDKRYRE
Host
Rabbit
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of TIRAP expression in transfected 293T cell line (H00114609-T01) by TIRAP MaxPab polyclonal antibody.
Lane 1: TIRAP transfected lysate(28.27 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of TIRAP transfected lysate using anti-TIRAP MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with TIRAP MaxPab mouse polyclonal antibody (B01) (H00114609-B01). -
Gene Info — TIRAP
Entrez GeneID
114609GeneBank Accession#
BC032474Protein Accession#
AAH32474.1Gene Name
TIRAP
Gene Alias
FLJ42305, Mal, wyatt
Gene Description
toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Gene Ontology
HyperlinkGene Summary
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq
Other Designations
MyD88 adapter-like protein|OTTHUMP00000179130|OTTHUMP00000179132|TIR domain-containing adapter protein|TIR domain-containing adaptor protein|Toll-interleukin 1 receptor (TIR) domain-containing adapter protein|Toll-interleukin 1 receptor (TIR) domain-conta
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Interactome
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Pathway
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Disease
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Publication Reference
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Phosphatidylinositol 4-Phosphate 5-Kinase α Facilitates Toll-like Receptor 4-mediated Microglial Inflammation through Regulation of the Toll/Interleukin-1 Receptor Domain-containing Adaptor Protein (TIRAP) Location.
Nguyen TT, Kim YM, Kim TD, Le OT, Kim JJ, Kang HC, Hasegawa H, Kanaho Y, Jou I, Lee SY.
The Journal of Biological Chemistry 2013 Feb; 288(8):5645.
Application:WB-Ce, Human, HeLa cells.
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Phosphatidylinositol 4-Phosphate 5-Kinase α Facilitates Toll-like Receptor 4-mediated Microglial Inflammation through Regulation of the Toll/Interleukin-1 Receptor Domain-containing Adaptor Protein (TIRAP) Location.
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