TIRAP MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of TIRAP expression in transfected 293T cell line (H00114609-T01) by TIRAP MaxPab polyclonal antibody.
Lane 1: TIRAP transfected lysate(28.27 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human TIRAP protein.
Immunogen
TIRAP (AAH32474.1, 1 a.a. ~ 256 a.a) full-length human protein.
Sequence
MASSTSLPAPGSRPKKPLGKMADWFRQTLLKKPKKRPNSPESTSSDASQPTSQDSPLPPSLSSVTSPSLPPTHASDSGSSRWSKDYDVCVCHSEEDLVAAQDLVSYLEGSTASLRCFLQLRDATPGGAIVSELCQALSSSHCRVLLITPGFLQDPWCKYQMLQALTEAPGAEGCTIPLLSGLSRAAYPPELRFMYYVDGRGPDGGFRQVKEAVMRYLQTLSWHLLYHGTPEIGVKLETENPCRASDSHKCDKRYRE
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of TIRAP expression in transfected 293T cell line (H00114609-T01) by TIRAP MaxPab polyclonal antibody.
Lane 1: TIRAP transfected lysate(28.27 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — TIRAP
Entrez GeneID
114609GeneBank Accession#
BC032474Protein Accession#
AAH32474Gene Name
TIRAP
Gene Alias
FLJ42305, Mal, wyatt
Gene Description
toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Gene Ontology
HyperlinkGene Summary
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq
Other Designations
MyD88 adapter-like protein|OTTHUMP00000179130|OTTHUMP00000179132|TIR domain-containing adapter protein|TIR domain-containing adaptor protein|Toll-interleukin 1 receptor (TIR) domain-containing adapter protein|Toll-interleukin 1 receptor (TIR) domain-conta
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Interactome
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Pathway
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Disease
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