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Last updated: 2017/12/10

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NLRP3 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00114548-T02
  • Visit Frequency :
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-NLRP3 full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 118.2
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-NLRP3 antibody (H00114548-D01P) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00114548-T02
    NLRP3 transfected lysate.
    Western Blot
    QC Testing of H00114548-T02
    Lane 1: NLRP3 transfected lysate ( 118.20 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Gene Name:
  • NLRP3
  • Gene Alias:
  • AGTAVPRL,AII,AII/AVP,AVP,C1orf7,CIAS1,CLR1.1,FCAS,FCU,FLJ95925,MWS,NALP3,PYPAF1
  • Gene Description:
  • NLR family, pyrin domain containing 3
  • Gene Summary:
  • This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq
  • Other Designations:
  • AII/AVP receptor-like,NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3,NACHT, LRR and PYD containing protein 3,OTTHUMP00000038408,OTTHUMP00000038409,OTTHUMP00000038410,PYRIN-containing APAF1-like protein 1,angiotensin/vasopressin receptor
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