LYK5 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
LYK5 transfected lysate.
Western Blot
Lane 1: LYK5 transfected lysate ( 38.39 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-LYK5 full-length
Host
Human
Theoretical MW (kDa)
38.39
Interspecies Antigen Sequence
Mouse (94)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-LYK5 antibody (H00092335-B01) by Western Blots.
SDS-PAGE Gel
LYK5 transfected lysate.
Western Blot
Lane 1: LYK5 transfected lysate ( 38.39 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — STRADA
Entrez GeneID
92335GeneBank Accession#
NM_153335Protein Accession#
NP_699166Gene Name
STRADA
Gene Alias
FLJ90524, LYK5, NY-BR-96, PMSE, STRAD, Stlk
Gene Description
STE20-related kinase adaptor alpha
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq
Other Designations
STE20-like pseudokinase|STE20-related adaptor protein|protein kinase LYK5
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